Wonder Woman returns in Injustice 2 as a playable character. She is voiced by the same voice actress whom had voiced her before, Susan Eisenberg. Just like the previous game, she sides with the regime. Later when Supergirl landed on earth, she mentored her. later, her Supergirl Tried to free Superman from his prison, but were stop by Blue Beetle and Firestorm. Because he needed help to fight Brainiac, Batman decide to free Superman himself. When Brainiac invaded the earth, she was among many whom were fighting against his army.
Wonder Woman and the other heroes were finally released from the Firestorm Matrix when Batman used the Lasso of Truth on Firestorm. Superman was still infected with the Kryptonite shard inside his nervous system, but Lex Luthor was able to extract it, saving Superman's life. Luthor also assembled a group of villains that defeated the Crime Syndicate. Later, at the Batcave, Wonder Woman and the Justice League talked about the enemy that destroyed the Crime Syndicate's world and came to the conclusion that Darkseid would return.