After a training session, Diana happened to come across Captain Steve Trevor during his escape from the Imperial German Army. A battle soon followed, as the Germans tracked Trevor to Themyscira, where they invaded in pursuit of Doctor Poison's notes. The loss of her aunt and realization of Mankind's downfall during the absence of the amazons convinced Diana to join the war effort, recognizing Ares as the instigator of the conflict.
In August 2010 (issue #600), J. Michael Straczynski took over the series' writing duties and introduced Wonder Woman to an alternate timeline created by the Gods in which Paradise Island had been destroyed and the Amazons scattered around the world. In this timeline, Diana is an orphan raised in New York. The entire world has forgotten Wonder Woman's existence and the main story of this run was of Diana trying to restore reality even though she does not properly remember it herself. A trio of Death Goddesses called The Morrigan acted as the main enemy of Wonder Woman. In this run, Wonder Woman wears a new costume designed by Jim Lee. Straczynski determined the plot and continued writing duties until Wonder Woman #605; writer Phil Hester then continued his run, which ultimately concluded in Wonder Woman #614.
After Diana's clash with Silver Swan, she goes to Greece, where Julia is staying. Here she meets Julia's friend, renowned Epigraphist Stavros Christadoulodou. Here, a conspiracy is shown to be in play with a mysterious woman behind it, dwelling in an undisclosed location, speaking to her servant Mikos about Diana's presence and how it could be a threat. A rebel group is revealed to be in existence, secretly fighting the witch's forces, headed by a man named Gregory, who had lost his son's to the witch's monsters. The witch uses her servants disguised as animals to kill her enemies in the rebel group. The rebel faction also has Katina and Spiros as it's members, actively tracking other followers of the witch and trying to keep Diana safe from harm. She goes on boat to an island called Cephalonia when she is distracted by another small island in the vicinity. She senses a strange presence in the island and is somehow attacked by it's mysterious resident psychically, as a warning, causing her to faint on the spot. In the hospital, Diana is surrounded by her friends and some wonder if it's the Magia, a curse that some believe is pure superstition. The Magia is said to come from the mysterious island, where a witch is said to exist. Diana is introduced to Theophilius Ventouras, one of the wealthiest people in the area by Julia, who is actually another pawn of the witch, and he deceives Diana and her friends into thinking the woman is actually a rich loner and there is no truth in the myths about the Magia and the Witch. Stavros meets with Gregory and is given a scroll that the faction had obtained from the island, which may contain secrets about the witch.
The Diana Prince alias also played an important role after the events of Infinite Crisis. Wonder Woman was broadcast worldwide killing a villain named Maxwell Lord, as he was mind controlling Superman into killing Batman. When Wonder Woman caught him in her lasso, demanding to know how to stop Superman, Maxwell revealed that the only way to stop him was to kill Lord, so as a last resort Diana snapped his neck. To recover from the trauma of killing another person, the Amazon went into a self-imposed exile for one year. On her return to public life, Diana realized that her life as a full-time celebrity superhero and ambassador had kept her removed from humanity. Because of this she assumed the persona of Diana Prince and became an agent at the Department of Metahuman Affairs. During a later battle with the witch Circe, a spell was placed on Diana leaving her powerless when not in the guise of Wonder Woman.