The events of Crisis on Infinite Earths greatly changed and altered the history of the DC Universe. Wonder Woman's history and origin were considerably revamped by the event. Wonder Woman was now an emissary and ambassador from Themyscira (the new name for Paradise Island) to Patriarch's World, charged with the mission of bringing peace to the outside world. Various deities and concepts from Greek mythology were blended and incorporated into Wonder Woman's stories and origin. Diana was formed out of clay of the shores of Themyscira by Hippolyta, who wished for a child; the clay figure was then brought to life by the Greek deities. The Gods then blessed and granted her unique powers and abilities – beauty from Aphrodite, strength from Demeter, wisdom from Athena, speed and flight from Hermes, Eyes of the Hunter and unity with beasts from Artemis and sisterhood with fire and the ability to discern the truth from Hestia. Due to the reboot, Diana's operating methods were made distinctive from Superman and Batman's with her willingness to use deadly force when she judges it necessary. In addition, her previous history and her marriage to Steve Trevor were erased. Trevor was introduced as a man much older than Diana who would later on marry Etta Candy. Instead, Perez created Julia and Vanessa Kapatelis, a Greek-American scholar and her teenage daughter whom Diana would live with when she was in Man's world and would be major supporting characters in the series for years.
Cheetah isn't the only one experiencing unexplained bouts of rage; this type of behavior is happening globally. Across the globe, thousands of people are lashing out in anger, rioting and swearing off the gods they once worshiped, all of them praising that these next gods, the Dark Gods, will be coming soon. According to Trevor, those that are affected by this rage are people whose confidence and belief in their respective gods is shaken, no matter who they are, and no matter what planet they come from.
DC Comics Executive Editor Dan DiDio asked fans for 600 postcards to restore the Wonder Woman comic book to the original numbering, starting at #600. The publisher's office had received 712 postcards by the October 31, 2009 deadline. As a result, the numbering switched to #600 after Wonder Woman #44, in an anniversary issue. Issue #600 featured several stories featuring work from guest creators such as Geoff Johns, George Pérez, Phil Jimenez, and Amanda Conner. The issue featured guest appearances from other female superheroes such as Batwoman, Power Girl, Batgirl, Stargirl and the Question.
Wonder Woman and the other heroes were finally released from the Firestorm Matrix when Batman used the Lasso of Truth on Firestorm. Superman was still infected with the Kryptonite shard inside his nervous system, but Lex Luthor was able to extract it, saving Superman's life. Luthor also assembled a group of villains that defeated the Crime Syndicate. Later, at the Batcave, Wonder Woman and the Justice League talked about the enemy that destroyed the Crime Syndicate's world and came to the conclusion that Darkseid would return.