Issue #600 introduced Wonder Woman to an alternate timeline created by the Gods in which Themyscira had been destroyed and the Amazons scattered around the world. In this timeline, Diana is an orphan raised in New York who is learning to cope with her powers. The entire world has forgotten Wonder Woman's existence and the main story of this run was of Diana trying to restore reality even though she does not properly remember it herself. Diana has no memories of her prior adventures as Wonder Woman, recollecting her memories in bits and pieces and receiving different abilities and resources (such as the power of flight and her lasso) during the progression of her adventure. A trio of Death Goddesses called The Morrigan acted as Wonder Woman's main enemies. Diana ultimately defeats the evil goddesses and returns everything back to normal.
At the Louvre, Diana watched a news report showing a signal fire burning at the Shrine of the Amazons and knew that it had been sent by her mother to warn of the impending invasion. Traveling to Gotham, she breaks into Bruce's base of operations to find him tinkering with a new prototype troop carrier, the Flying Fox. It reminds her of someone she thinks of who would have loved to have flown it. Bruce tells her that he believes an invasion is imminent; she corrects him. It has already arrived.
Wonder Woman and the other heroes were finally released from the Firestorm Matrix when Batman used the Lasso of Truth on Firestorm. Superman was still infected with the Kryptonite shard inside his nervous system, but Lex Luthor was able to extract it, saving Superman's life. Luthor also assembled a group of villains that defeated the Crime Syndicate. Later, at the Batcave, Wonder Woman and the Justice League talked about the enemy that destroyed the Crime Syndicate's world and came to the conclusion that Darkseid would return.