The New 52 universe does not have a "Diana Prince" identity as stated in an interview by series writer Brian Azzarello. However, when she and Superman began dating, for her civilian identity she used the Diana Prince alias whenever she was around Clark Kent; such as when she introduced herself to Lois Lane at Lois's housewarming party under that name.
Impressed by this unknown woman's self-sacrifice, the Amazons entombed her with honors and clothed her in armor displaying the American flag pattern on her uniform, which they assumed were her heraldic colors. Trevor's legacy was also the primary reason why Ares arranged for Steve Trevor to bomb the island, as he could not resist the irony of the heroine's son unwittingly killing her admirers.
After preventing a terrorist attack at a refugee camp in Greece, Wonder Woman returned to a government facility in the United States and was examined by a sickly doctor, Dr. Shannon Crawford. That evening, Diana attended the wedding of Etta Candy's brother, where she discovered a bomb seconds away from detonation hidden underneath one of the tables. She was able to contain the blast, but Etta was injured by a piece of shrapnel. She returned Etta to Dr. Crawford who removed the shrapnel, before touching Wonder Woman with an Amazon-strength sedative she had developed, leaving Diana too weak to fight back. Dr. Crawford told Diana that she had a rare genetic illness, and that she intended to use Diana's Amazon blood to develop a cure, saving her life as well as providing life-saving treatment for others afflicted with the same disease. Diana awoke to discover Crawford had developed Amazonian strength as a result of the blood transfusion. She was able to bind Dr. Crawford in the Lasso of Truth, which rejected the lie and restored Crawford to her previous state. Having lost hope for a cure, Crawford injected herself with the sedative, killing her. Wonder Woman was too late to stop her, but she understood Crawford's decision to end her pain and held her as she died.
Wonder Woman and the other heroes were finally released from the Firestorm Matrix when Batman used the Lasso of Truth on Firestorm. Superman was still infected with the Kryptonite shard inside his nervous system, but Lex Luthor was able to extract it, saving Superman's life. Luthor also assembled a group of villains that defeated the Crime Syndicate. Later, at the Batcave, Wonder Woman and the Justice League talked about the enemy that destroyed the Crime Syndicate's world and came to the conclusion that Darkseid would return.