A shocked Diana apologized to Antiope and abruptly left the training session. She wandered off to a cliff on the Themysciran seashore and examined her gauntlets in awe. As she stood there, she noticed an airplane burst through the forcefield surrounding Themyscira and crash in the nearby waters. Seeing even from a great distance away that someone was trapped inside the sinking aircraft, she leaped down the ocean and rescued the pilot, none other than a human soldier named Steve Trevor. She pulled him out of the water and onto the Themysciran shore. As he came to, she noted in disbelief that he was a man, as she had never seen one before. Though somewhat confused, Steve affirmed that he was, rhetorically asking whether or not he looked like one.
Issue #600 introduced Wonder Woman to an alternate timeline created by the Gods in which Themyscira had been destroyed and the Amazons scattered around the world. In this timeline, Diana is an orphan raised in New York who is learning to cope with her powers. The entire world has forgotten Wonder Woman's existence and the main story of this run was of Diana trying to restore reality even though she does not properly remember it herself. Diana has no memories of her prior adventures as Wonder Woman, recollecting her memories in bits and pieces and receiving different abilities and resources (such as the power of flight and her lasso) during the progression of her adventure. A trio of Death Goddesses called The Morrigan acted as Wonder Woman's main enemies. Diana ultimately defeats the evil goddesses and returns everything back to normal.
Superman begged his fellow heroes to arrest him, and while he was taken to the A.R.G.U.S. facilities, Diana expressed disapproval at Steve’s secret Justice League. Wonder Woman travelled to the Temple of Hephaestus and demanded Hephaestus tell her about what the box really was. Hephaestus answered that the box was not created by the Gods of Olympus and the truth was a mystery even to them. Wonder Woman decided to seek help from the Justice League Dark. Suddenly, the three Justice Leagues converged at the House of Mystery, where the heroes were divided, one side led by Wonder Woman, the other by Batman. Zatanna, having taken Wonder Woman’s side, teleported the group away. Wonder Woman’s group tracked Pandora’s box to Lex Luthor’s prison cell, where Pandora was offering the box to Luthor. Wonder Woman grabbed the box but was overwhelmed by its power.
Flash and Cyborg save all the hostage, which Silas Stone tells Victor that Steppenwolf can not get the final Mother Box. Batman then jumps down into the Knightcrawler and saves Wonder Woman after a Parademon manages to briefly knock her out. The Knightcrawler gets attacked by Steppenwolf, and Barry helps Wonder Woman get her sword so she can help Batman.
Wonder Woman's supporting characters were altered as well. In addition to the introduction of the Kapatelises, Steve Trevor was changed into an Air Force officer considerably older than Diana, thus sidestepping the traditional romance between the two. Instead, Trevor became involved with Etta Candy, a mature military officer possessing a plump physique. The Greek war god Ares and the witch Circe eventually became two of Diana's greatest enemies. Her rogues gallery included the Cheetah, a woman who could transform into a ferocious feline-humanoid creature; and the Silver Swan, a once-deformed radiation victim granted beauty, wings and deafening sonic powers through genetic engineering.